| Cross Linker (DVB): | 1% |
| Particle Size (mesh): | 100-200 |
| Loading (-Cl:mmol/g resin): | 1.0-3.0 |
| Sulfonyl chloride resin is a widely used reagent and can be applied in organic synthesis. It can react with alcohols to generate polymer-supported tosylates, which can then be cleaved with nucleophiles to generate secondary and tertiary amine, thioethers and N-alkylimidazoles [1-3]. This approach has been employed to prepared oxazolidinones by a cyclative cleavage strategy involving intramolecular aminolysis of the polymer-bound tosylate [4]. It can also be used as an efficient solid-supported condensation reagent for the solution phase synthesis of esters [5] or a derivative azide transfer reagent to prepare α-diazo ketones [6]. Chiral amine can also be supported on this resin to reduce the aromatic ketone to secondary alcohols [7]. References [1] J. J. Reuter, et al., Tetrahedron Lett., 1998, 39, 975 [2] E. W. Baxter, et al., Tetrahedron Lett., 1998, 39, 979 [3] Y. Hu, et al., ECSOC-2 www.mdpi.org/ecsoc, b0003, 1998 [4] P. T. Holte, et al., Eur. J. Org. Chem., 2001, 2965 [5] N. Zander, et al., Tetrahedron Lett., 2001, 42, 7783 [6] M. Gary, et al., J. Org., Chem., 2001, 66, 2509 [7] J. B. Hu, et al., J. Org. Chem., 2001, 66, 303 |
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