| Cross Linker (DVB): | 1% |
| Particle Size (mesh): | 200-400 |
| Loading (mmol/g): | 0.6-1.0 |
| Rink resin is an acid labile resin widely used to prepare amides [1], amide derivatives, and other organic molecules [2-5]. For example, Rink’s amide linker can be employed directly as an alkylated diversity scaffold to yield N-alkylated amides upon cleavage from the solid support. Although the rink technology is limited to the preparation of amides and carboxylic acids, the utility of Rink-chloride can allow the attachment of various nucleophiles with a wide range of functional groups to the resin, such as amines, alcohols and thiols [2].In addition, the method of Rink resin trifluoroacetate can be used to prepare phenols [3] and purines [4,5]. Refenences [1] H. Rink Tetrahedron Lett., 1987, 28,3787. [2] S. L. Mellor & W. C. Chan J. Chem. Soc., Chem. Commun., 1997, 2005. [3] R. S. Garigipati Tetrahedron Lett., 1997, 38,6807. [4] W. K. D. Brill, et al. Synlett., 2001, 7,1097. [5] W. K. D. Brill & C. Riva-Toniolo Tetrahedron Lett., 2001, 42,6515. |
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