| Cross Linker (DVB): | 1% |
| Particle Size (mesh): | 100-200 |
| Loading (mmol/g): | 0.3-1.0 |
| Rink Amide-MBHA resin is less acid sensitive than Rink Amide resin because the benzhydrylamine linker is joined to the support through an electron-withdrawing acetamido spacer [1]. Normally the product is detached from the resin using 95%TFA in DCM plus scavengers as required by the composition of the substrate [1,2]. However, it is also useful for preparing peptides. Boussard, Cyrille et al. has recently reported that. Syntheses of tri- and tetra- and pentapeptides were performed via a solid phase synthesis methodology using a Rink Amide MBHA resin [3]. References [1] Bernatowicz, M. S.; Daniels, S. B.; Köster, H. Tetrahedron Lett. 1989,30,4645. [2] M. Lebl, et al., J. Comb. Chem., 1999, 1, 474 [3] Boussard, Cyrille et al. European Journal of Medicinal Chemistry,37(11),2002, pp.883-890. |
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