| CAS #: | 386213-32-7 |
| Molecular Formula: | C33H32N2O8 |
| Molecular Weight: | 584.62 |
| Fmoc-Lys(Mca)-OH is a building block for the synthesis of fluorophore-labeled peptides and DABCYL- or Dnp-quenched fluorescent peptide substrates, and a modified lysine derivative for the preparation of fluorogenically-labeled peptides by Fmoc chemistry. Recently, Fmoc-Lys(Mca)-OH has been used to prepare lanthanide-based luminescent proteins by native chemical ligation. Lys(Mca) was found to be stable to HF cleavage conditions used to synthesize the thioester fragments needed for ligation. References 1. J. L. Lauer-Fields, et al. (2001) Biochemistry, 40, 5795. 2. C. F. W. Becker, et al. (2004) Bioconjugate Chem., 15, 1118. |
|
