| Synonym: | N-α-Fmoc-N-ε-Biotinyl-L-lysine |
| CAS #: | 146987-10-2 |
| Molecular Formula: | C31H38N4O6S |
| Molecular Weight: | 594.7 |
| Fmoc-Lys(Biotin)-OH is a modified lysine derivative for the preparation of biotin-labeled peptides by Fmoc SPPS. It is useful for preparing specifically labeled peptides to use as probes. The biotinylated peptides are detected using labeled avidin or streptavidin which tightly bind to biotin. Because labeled avidin or streptavidin are labeled in multiple sites, the binding of labeled avidin to a biotinylated probe produces an amplified response compared to the direct incorporation of the label into the peptide. Biotinylation can modify the activity of a peptide. Recently, biotinylation of lysine residues in exendin-4 was reported to improve the hypoglycemic effects of the peptide. Significantly, incorporation of Lys(biotin) led to an product that could be taken orally. References 1. Jin, C.H., et al.A new orally available glucagon-like peptide-1 receptor agonist, biotinylated exendin-4,displays improved hypoglycemic effects in db/db mice[J]. J. Control Release 2009, 133, 172. |
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