| Synonyms: |
Fmoc-L-propargylglycine Fmoc-Pra-OH |
| CAS #: | 198561-07-8 |
| Molecular Formula: | C20H17NO4 |
| Molecular Weight: | 335.3 |
| Fmoc-Gly(Propargyl)-OH is a Fmoc protected glycine derivative useful for proteomics studies and solid phase peptide synthesis techniques. Glycine is the simplest, and least sterically hindered of the amino acids, which confers a high level of flexibility when incorporated into polypeptides. This unusual amino acid can be used in Solid Phase Peptide Synthesis (SPPS) as: (1). a precursor to the tritium-induced Norvaline peptides; (2). in the synthesis of branched peptides using a palladium-catalyzed coupling reaction; (3). as a reagent in the dual-catalyst Sonogashira coupling reaction. References 1. Eberle, A. N.; Zeller, A. Tritiation of Peptides to High Specific Radioactivity. Part 1. Synthesis and Biological Properties of [13-(3H4)Norvaline]-α-MSH and of [2,23-Bis((3H2)tyrosine)]ACTH(1-24). Helvetica Chim. Acta. 1985 (68) 1880-1892. 2. Crisp, G. T.; Robertson, T. A. Palladium-catalyzed coupling of a propargylglycinededrivative. Tetrahedron. 1992 (48) 3239-3250. 3. Sonogashira, K.; Tohda, Y.; Haghiara, N. A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes, and bromopyridines.Tetrahedron Lett.,1975 (16) 4467-4470. |
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