Rink Amide Resin
(100-200 mesh, 0.6-1.0 mmol/g)

           
Product Catalog # SizePrice (USD) Quantity
$267.00
$800.00
$3,150.00
Cross Linker (DVB): 1%
Particle Size (mesh): 100-200
Loading (mmol/g): 0.6-1.0
Rink resin is an acid labile resin widely used to prepare amides [1], amide derivatives, and other organic molecules [2-5]. For example, Rink’s amide linker can be employed directly as an alkylated diversity scaffold to yield N-alkylated amides upon cleavage from the solid support. Although the rink technology is limited to the preparation of amides and carboxylic acids, the utility of Rink-chloride can allow the attachment of various nucleophiles with a wide range of functional groups to the resin, such as amines, alcohols and thiols [2].In addition, the method of Rink resin trifluoroacetate can be used to prepare phenols [3] and purines [4,5].
Refenences
[1] H. Rink Tetrahedron Lett., 1987, 28,3787.
[2] S. L. Mellor & W. C. Chan J. Chem. Soc., Chem. Commun., 1997, 2005.
[3] R. S. Garigipati Tetrahedron Lett., 1997, 38,6807.
[4] W. K. D. Brill, et al. Synlett., 2001, 7,1097.
[5] W. K. D. Brill & C. Riva-Toniolo Tetrahedron Lett., 2001, 42,6515.