| Cross Linker (DVB): | 1% |
| Particle Size (mesh): | 200-400 |
| Loading (mmol/g resin): | 0.6-2.0 |
| The formyl resin can be used as a support for primary amines, or as a solid-phase support/protecting group for diols [1-2]. Formylpolystyrene has been employed to prepare a range of 2,5 disubstituted tetrahydrofurans via the electrophilic rearrangement of isoxazolines [3]. This resin reacts easily with nucleophiles, such as organolithium reagents, Grignard reagents, and Witting reagents, leading to a variety of modified resin [4]. References [1] J. M. J. Frechet, et al. , J. Chem. Soc. ,Chem. Commun. , 1975, 225 [2] S. Hanessian., et al. , Carbohyd. Res., 1974, 38, C-15 [3] X. Beebe, et al., J. Am. Chem. Soc., 1992, 114, 10061 [4] M. Cernerud, et al. , Tetrahedron: Asymmetry, 1996, 7, 2863 |
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