| Synonym: | N-α-Fmoc-O-benzyl-L-phosphothreonine |
| CAS #: | 175291-56-2 |
| Molecular Formula: | C26H26NO8P |
| Molecular Weight: | 511.5 |
| Fmoc-Thr(HPO3Bzl)-OH is an excellent building block for the preparation of phosphopeptides . This derivative can be introduced using standard activation methods, such as PyBOP and TBTU. The monoprotected phosphothreonine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods . References 1. P. White & J. Beythien in “Innovations & Perspectives in Solid Phase Synthesis and Combinatorial Libraries, 4th International Symposium”, Mayflower Scientific Ltd., Birmingham, 1996, pp. 557. 2. T. Vorherr, et al. (1995) Bioorg. Med. Chem. Lett., 5, 2661. |
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