Products > Resins for Peptide Synthesis > Sulfonyl Chloride Resin
Sulfonyl Chloride Resin
Catalog # |
Cross Linker (DVB) |
Particle Size
(mesh) |
Loading
(-Cl:mmol/g resin)
|
Price (US $) |
25 g |
100 g |
500g |
151907
151908 |
1%
1% |
100-200
200-400 |
1.0-3.0
1.0-3.0 |
316.00
316.00 |
742.00
742.00 |
2,168.00
2,168.00 |
|
Sulfonyl chloride resin is a widely used reagent and can be applied in organic synthesis. It can react with alcohols to generate polymer-supported tosylates, which can then be cleaved with nucleophiles to generate secondary and tertiary amine, thioethers and N-alkylimidazoles [1-3]. This approach has been employed to prepared oxazolidinones by a cyclative cleavage strategy involving intramolecular aminolysis of the polymer-bound tosylate [4]. It can also be used as an efficient solid-supported condensation reagent for the solution phase synthesis of esters [5] or a derivative azide transfer reagent to prepare α-diazo ketones [6]. Chiral amine can also be supported on this resin to reduce the aromatic ketone to secondary alcohols [7].
References
[1] J. J. Reuter, et al., Tetrahedron Lett., 1998, 39, 975
[2] E. W. Baxter, et al., Tetrahedron Lett., 1998, 39, 979
[3] Y. Hu, et al., ECSOC-2 www.mdpi.org/ecsoc, b0003, 1998
[4] P. T. Holte, et al., Eur. J. Org. Chem., 2001, 2965
[5] N. Zander, et al., Tetrahedron Lett., 2001, 42, 7783
[6] M. Gary, et al., J. Org., Chem., 2001, 66, 2509
[7] J. B. Hu, et al., J. Org. Chem., 2001, 66, 303
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