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> Sieber Resin
Sieber Resin
(9-Fmoc-Aminoxanthen-3-yloxy-polystyrene resin)
|
Catalog # |
Cross Linker (DVB) |
Particle Size
(mesh) |
Loading
(mmol/g) |
Price (US $) |
5 g |
25 g |
100 g |
500 g |
151901
151902 |
1%
1% |
100-200
200-400 |
0.2-0.8
0.2-0.8 |
250.00
250.00 |
750.00
750.00 |
1,875.00
1,875.00 |
5,625.00
5,625.00 |
In 1987, Sieber [1] described the preparation of the xanthenyl linker (Sieber linker) allowing the synthesis of amidesunder very mild cleavage conditions (TFA/DCE/EDT (2:98:0.1)). Sieber resin is an excellent support for the synthesis of protected peptide amides and carboxamides. The resin was used in preparation of amides [2], cyanobiaryls [3] and glycopeptides [4,5]. Carboxylic acids can be coupled to deprotected Sieber resin under standard conditions [6,7]. Cleavage is effected by 1% TFA.
References
[1] P. Sieber, Tetrahedron Lett. 1987, 28, 2107
[2] T. Srinivasan, et al., Bioorg. Med. Chem. Lett. 2002, 12, 2803
[3] N. D. Hone, et al., Tetrahedron Lett., 2001, 42, 1115
[4] Y. Nakahara, et al., Tetrahedron Lett., 2000, 41, 6489
[5] Y. Nakahara, et al., Biosci. Biotechnol. Biochem., 2001, 65, 1358
[6] R. Knorr,et al., Tetrahedron Lett., 1989, 30, 1927
[7] J. M. Matsoukas, et al., J. Med. Chem. 1996, 39, 3585 |
