Products > Resins for Peptide Synthesis > Rink Amide Resin
Rink Amide Resin
Catalog # |
Cross Linker (DVB) |
Particle Size
(mesh) |
Loading
(mmol/g) |
Price (US $) |
25 g |
100 g |
500 g |
151801 151802 151803 151804 |
1%
1%
1%
1% |
100-200
100-200
200-400
200-400 |
0.3-0.6
0.6-1.0
0.3-0.6
0.6-1.0 |
250.00
267.00
250.00
267.00 |
750.00
800.00
750.00
800.00 |
2,950.00
3,150.00
2,950.00
3,150.00 |
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Rink resin is an acid labile resin widely used to prepare amides [1], amide derivatives, and other organic molecules [2-5]. For example, Rink's amide linker can be employed directly as an alkylated diversity scaffold to yield N-alkylated amides upon cleavage from the solid support. Although the rink technology is limited to the preparation of amides and carboxylic acids, the utility of Rink-chloride can allow the attachment of various nucleophiles with a wide range of functional groups to the resin, such as amines, alcohols and thiols [2].In addition, the method of Rink resin trifluoroacetate can be used to prepare phenols [3] and purines [4,5].
Refenences
[1] H. Rink Tetrahedron Lett., 1987, 28,3787.
[2] S. L. Mellor & W. C. Chan J. Chem. Soc., Chem. Commun., 1997, 2005.
[3] R. S. Garigipati Tetrahedron Lett., 1997, 38,6807.
[4] W. K. D. Brill, et al. Synlett., 2001, 7,1097.
[5] W. K. D. Brill & C. Riva-Toniolo Tetrahedron Lett., 2001, 42,6515.
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