PyBOP
(Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate)
CAS
#: |
128625-52-5
|
Molecular
Formula:
|
C18H28F6N6OP2
|
Molecular
Weight:
|
520.4
|
Melting
Point:
|
156
- 159°C
|
Appearance:
|
white
powder
|
Purity
(HPLC):
|
≥99.00%
|
|
Catalog
# |
Quantity
|
Price
(US $) |
121601
|
25
g |
25.00 |
100
g |
80.00 |
500
g |
350.00 |
1
kg |
550.00 |
PyBOP is a peptide coupling reagent used in solid phase peptide synthesis. It is used as a substitute for the BOP reagent, thus avoiding the formation of the carcinogenic side product HMPA. Contrary to activation with uronium/aminium-type coupling reagents, by-products resulting from guanidinylation of the amino group cannot be formed. PyBOP has been used as well for obtaining peptide thioesters.
References
1. Coste, J.; Le-Nguyen, D.; Castro, B. (1990). "PyBOP: A new peptide coupling reagent devoid of toxic by-product". Tetrahedron Letters 31 (2): 205.
|