Resins for Solid Phase Peptide Synthesis: Application Guide
Resins for Fmoc SPPS
Products
Resins
Attachment
Cleavage
Peptide Acid
Wang Resin
DIC/HOBt/DMAP
95%TFA/Scavenger
4-Benzyloxybenzyl bromide Resin
Cesium salt or KF
95% TFA/Scavenger
Protected Peptide Acid
2-Chlorotrityl Chloridde Resin
DIPEA
EtOH/TFE/DCM(1:2:7) 1%TFE in DCM
HMBA-MBHA Resin
60%TFA in DCM
Peptide Amide
Rink Amide Resin
HOBt/HBTU/DIPEA
Rink Amide-MBHA Resin
Rink Amide-AM Resin
Amine
Protected Peptide Amide
Sieber Resin
1% TFA in DCM
Peptide Ester
ROH/DIEA/DMF
Peptide Hydrazide
Hydrazine/DMF
Hydrazine-2-Chlorotrityl Resin
DIC/HOBt
1% to 5% TFA in DCM
Resins for Boc SPPS
Merrifield Resin
HF or TFMSA
Hydroxymethyl Resin
HFor TFMSA
PAM Resin
Oxime Resin
NaOH/Dioxane
MBHA Resin
BHA Resin
HF
Hydrazine/ DMF
MeOH/DMF/TEA
Bead Size Conversion Table
Mesh
µm
20
850
60
250
200
75
25
710
70
212
325
45
35
500
100
150
400
38
50
300
140
106
