Products > Resins for Peptide Synthesis > Wang Resin




Wang Resin
(4-Benzyloxybenzyl Alcohol Resin)


Catalog #

Cross Linker (DVB)

Particle Size
(mesh)

Loading
(mmol/g)

Price (US $)

25 g

100 g

500 g

152501
152502
152503
152504

1%
1%
1%
1%

100-200
100-200
200-400
200-400

0.4-1.0
1.0-2.0
0.4-1.0
1.0-2.0

152.00
157.00
152.00
157.00

260.00
278.00
260.00
278.00

783.00
863.00
783.00
863.00



Wang resin is the most popular support for solid phase organic synthesis (SPOS) using Fmoc chemistry. As a standard support it can be used for the solid phase immobilization of acids [1,2] and phenols [3-5] for SPOS. The ester linkage may be achieved, which has good stability to a variety of reaction conditions, but can be readily removed with the moderate acid treatment, generally with trifluoroacetic acid [6]. For the immobilization of amines, Wang resin also can be readily converted into solid phase equivalents of standard urethane-based protecting groups by reaction with phosgene or activated carbonates, such as carbonyl diimidazole or bis(p-nitropnenyl)-carbonate [7].

References

[1] S. S. Wang, J. Am. Chem. Soc., 1973, 95, 1328
[2] G. Lu, et al., J. Org. Chem., 1981, 46, 3433
[3] V. Krchnák, et al., Tetrahedron Lett., 1995, 36, 6193
[4] Y. Wang & S. R. Wilson, Tetrahedron Lett., 1997, 38, 4021
[5] A. Dahan, et al., Macromolecules, 2003, 36, 1034
[6] S. Kiselyov & R.W. Amstrong, Tetrahedron Lett., 1997, 38, 6163
[7] J. R. Hauske, et al., Tetrahedron Lett., 1995, 36, 1589

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