Products > Resins for Peptide Synthesis > Sieber Resin




Sieber Resin
(9-Fmoc-Aminoxanthen-3-yloxy-polystyrene resin)


Catalog #

Cross Linker (DVB)

Particle Size
(mesh)

Loading
(mmol/g)

Price (US $)

5 g

25 g

100 g

500 g

151901
151902

1%
1%

100-200
200-400

0.2-0.8
0.2-0.8

250.00
250.00

750.00
750.00

1,875.00
1,875.00

5,625.00
5,625.00



In 1987, Sieber [1] described the preparation of the xanthenyl linker (Sieber linker) allowing the synthesis of amidesunder very mild cleavage conditions (TFA/DCE/EDT (2:98:0.1)). Sieber resin is an excellent support for the synthesis of protected peptide amides and carboxamides. The resin was used in preparation of amides [2], cyanobiaryls [3] and glycopeptides [4,5]. Carboxylic acids can be coupled to deprotected Sieber resin under standard conditions [6,7]. Cleavage is effected by 1% TFA.

References

[1] P. Sieber, Tetrahedron Lett. 1987, 28, 2107
[2] T. Srinivasan, et al., Bioorg. Med. Chem. Lett. 2002, 12, 2803
[3] N. D. Hone, et al., Tetrahedron Lett., 2001, 42, 1115
[4] Y. Nakahara, et al., Tetrahedron Lett., 2000, 41, 6489
[5] Y. Nakahara, et al., Biosci. Biotechnol. Biochem., 2001, 65, 1358
[6] R. Knorr,et al., Tetrahedron Lett., 1989, 30, 1927
[7] J. M. Matsoukas, et al., J. Med. Chem. 1996, 39, 3585