Products > Peptide Coupling Reagents > PyBOP




PyBOP
(Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate)

               CAS #:
128625-52-5
               Molecular Formula:
C18H28F6N6OP2
               Molecular Weight:
520.4
               Melting Point:
156 - 159°C
               Appearance:
white powder
               Purity (HPLC):
≥99.00%


Catalog #
Quantity
Price (US $)
121601
25 g
25.00
100 g
80.00
500 g
350.00
1 kg
550.00


PyBOP is a peptide coupling reagent used in solid phase peptide synthesis. It is used as a substitute for the BOP reagent, thus avoiding the formation of the carcinogenic side product HMPA. Contrary to activation with uronium/aminium-type coupling reagents, by-products resulting from guanidinylation of the amino group cannot be formed. PyBOP has been used as well for obtaining peptide thioesters.

References

1. Coste, J.; Le-Nguyen, D.; Castro, B. (1990). "PyBOP: A new peptide coupling reagent devoid of toxic by-product". Tetrahedron Letters 31 (2): 205.
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