Products > Peptide Coupling Reagents > HOAt





HOAt
(1-Hydroxy-7-azabenzotriazole)

               CAS #:
39968-33-7
               Molecular Formula:
C5H4N4O
               Molecular Weight:
136.1
               Appearance:
yellow crystalline powder
               Purity (HPLC):
≥99.00%


Catalog #
Quantity
Price (US $)
120805
25 g
95.00
100 g
295.00
500 g
885.00
1 kg
1,325.00


HOAt is a coupling additive in peptide synthesis, also used in segment coupling.
It is described as a more efficient additive which speed up coupling process reduces the loss of chiral integrity, and provide a visual indication (yellow-to-colorless).

References

1. Carpino, L.A. 1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive. J. Am.Chem. Soc. 1993, 115, 4397-4398.