Products > Peptide Coupling Reagents > HCTU





HCTU
(2-(6-Chloro-1H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexafluorophosphate)

               CAS #:
330645-87-9
               Molecular Formula:
C11H15N5OPF6Cl
               Molecular Weight:
413.7
               Appearance:
white powder
               Purity (HPLC):
≥98.00%


Catalog #
Quantity
Price (US $)
120804
25 g
30.00
100 g
75.00
500 g
300.00
1 kg
500.00


HCTU is a novel aminium-based coupling reagent, analogous to HBTU, which in comparative studies was found to give superior results to TBTU in the synthesis of difficult peptides, in hindered couplings, and cyclizations. HCTU is also reported to be less allergenic than other coupling reagents.

References

1. O. Marder, et al. (2002) Chimica Oggi, 37.
2. G. Sabatino, et al. in "Peptides 2002, Proceedings of the 27th European Peptide Symposium", E. Benedetti & C. Pedone (Eds), Naples, Edizioni Ziino, 2002, pp. 272.
3. M. Gude & S. Barthélémy in "Peptides 2002, Proceedings of the 27th European Peptide Symposium", E. Benedetti & C. Pedone (Eds), Naples, Edizioni Ziino, 2002, pp. 122.
4. G. Sabatino, et al. in "Peptide Revolution: Genomics, Proteomics & Therapeutics, , Proc. 18th American Peptide Symposium", M. Chrev & T. K. Sawyer (Eds), Cardiff, American Peptide Society, 2003, pp. 49.
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