Products > Peptide Coupling Reagents > HATU




HATU
(2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate)

               CAS #:
148893-10-1
               Molecular Formula:
C10H15F6N6OP
               Molecular Weight:
380.2
               Melting Point:
183 - 185°C
               Appearance:
white powder
               Purity (HPLC):
≥99.00%


Catalog #
Quantity
Price (US $)
120801
25 g
35.00
100 g
130.00
500 g
600.00
1 kg
1,000.00


HATU is a highly efficient coupling reagent for solid and solution phase peptide synthesis. In comparative studies, HATU has been found to give better coupling yields with less enantiomerization than HBTU, TBTU or PyBOP. It is particularly effective at coupling to N-alkyl amines where other coupling reagents give poor yields and is the preferred reagent for loading resins bearing secondary amino groups. HATU is also used in rapid automated derivatization of solid-phase supports for oligonucleotide synthesis.

References

1. L. A. Carpino (1993) J. Am. Chem. Soc., 115, 4397.
2. F. Albericio, et al. (1998) J. Org. Chem., 63, 9678.
3. J. A. Carpino, et al., in "Innovation & Perspectives in Solid Phase Synthesis, 3rd International Symposium", R. Epton (Ed.), Mayflower Worldwide Ltd., 1994, pp. 95.
4. Tetrahedron Lett. 1997, 38, 3331.
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