Products > Fmoc Amino Acids > Fmoc Amino Acids - Lys > Fmoc-Lys(ivDde)-OH


Fmoc-Lys(ivDde)-OH
(Fmoc-Nε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-lysine)



          CAS #:
204777-78-6
          Molecular Formula:
C34H42N2O6
          Molecular Weight:
574.7
          Purity:
≥95%


Catalog #
Quantity
Price (US $)
101224
5 g
400.00
25 g
1,350.00

Fmoc-Lys(ivDde)-OH is especially useful for preparing peptides selectively modified on the Lys sidechain, such as peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys sidechain. The ivDde protective group possesses higher orthogonality regarding Boc and Fmoc in comparison to Dde. The ivDde group can be selectively removed with hydrazine in the presence of acid labile groups such as t-butyl and trityl based protecting groups.

References

1. Chhabra, S.R .; et al. Tetraheron Lett. 1998, 39, 1603-9